吡啶联吡唑类化合物合成及性质研究

文档编号:HG148  文档字数:9811,页数:32

摘 要：本文档以3-氨基-2氯吡啶为原料，经过重氮化，还原成肼基，再环和得到吡唑取代基酯类，最后水解等四步反应得到中间体5-甲基-1-（2-氯吡啶-3基） -4-吡唑羧酸,再以它为母体，经过酰氯化，再与不同取代基的苯胺反应得到系列1酰胺类目标产物。另外，以1-（吡啶-3-基）-5-三氟甲基-1H-4-吡唑羧酸为中间体，经过酰氯化，再与不同取代基的苯胺反应得到系列2酰胺类目标产物。
 得到的29个产物经核磁、质谱和熔点测定进行结构表征。并对其进行生物活性研究。
关键词：吡啶，吡唑，吡啶联吡唑，酰胺，生物活性

Abstract: A synthetic method of pyridine-compound pyrazole was design. An intermediate 5-methyl-(2-chloro-pyridine-3-)-pyrazole-4-carboxylic acid was explored.It was performed by using 3-amino-2-chloro pyridine as the starting materials in three steps including diazotization,reduction and cyclize to form the attempted product. Using it to acyl chloride,then reacted with different substituted aniline to obtain attempted 1st series acylamide,; At the same time, using 1 - (pyridine-3) -5 - trifluoromethyl -pyrazole-4-carboxylic acid as an intermediates, according to acyl chloride,then reacted with different substituted aniline to obtain attempted 2sec series acylamide.
 The structural characterization of the getted 29 product was study by H-NMR,MS and M.p apparatus.Then study their biological active.
Keywords：pyridine; pyrazole; acyl chloride; synthesis,biological active;

目  录
中文摘要 I
英文摘要 II
目录 III
1. 绪论 1
 1.1  吡啶类农药的研究进展 1
 1.2  吡唑类农药的研究进展 1 
 1.3  酰胺类农药的研究进展 1
 1.4  含吡唑基吡啶类化合物 2
 1.5  含吡唑基、吡啶基酰胺类化合物 3
 1.6  合成路线 4
2. 实验部分 7
 2.1  仪器与试剂 7
 2.2  试验操作 7
3. 结果与讨论 10
 3.1   试验结果 10
 3.2   讨论 22
 3.3   生测结果 24
4．总结与展望 25
致谢 26
参考文献 27

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