DL－苏式－对甲砜基苯基丝氨酸乙酯的拆分

文档编号:SW025  文档字数:9610,页数:23

摘要:本文根据外消旋体的性质，通过在DL-苏式-对甲砜基苯基丝氨酸乙酯盐酸盐的饱和溶液中加入D-苏式-对甲砜基苯基丝氨酸乙酯盐酸盐晶种诱导D-苏式-对甲砜基苯基丝氨酸乙酯盐酸盐结晶的方法和利用手性试剂酒石酸将外消旋体中的两种对映体转化为非对映异构体，再用氨水调节溶液pH，使D-苏式-对甲砜基苯基丝氨酸乙酯的酒石酸盐从溶液析出的方法使DL-苏式-对甲砜基苯基丝氨酸乙酯得到拆分。

关键词：外消体；DL-苏式-对甲砜基苯基丝氨酸乙酯；手性拆分；

Chiral resolution of DL-threo-3-(4-methylsulfonylphenyl) serinate ethyl ester compound

Abstract: According to raceme of nature, we have tow methods to separate the DL-threo-3-(4-methylsulfonylphenyl) serinate ethyl ester. One is that adding a few of crystal of D-threo-3-(4-methylsulfonylphenyl) serinate ethyl ester to the saturated solution of the raceme make the D-threo-3-(4-methylsulfonylphenyl) serinate ethyl ester hydrochloride crystallize. The other method has the use of chiral reagents. The tartaric acid will change DL-threo-3-(4-methylsulfonylphenyl) serinate ethyl ester into non-enantiomer. Ammonia was used to adjust the solution’s pH value to 7.8.That D-threo-3-(4-methylsulfonylphenyl) serinate ethyl ester precipitate. The two methods for chiral resolution are feasible.
 Keywords: racemization; DL-threo-3-(4-methylsulfonylphenyl) serinate ethyl ester; chiral resolution
 
目 录
中文摘要 I
英文摘要 II
目 录 III
1  绪论 1
 1.1  背景 1
 1.2  拆分方法 2
2  实验部分 8
 2.1  仪器与试剂 8
 2.2  分析方法 8
 2.3  DL-苏式-对甲砜基苯基丝氨酸乙酯拆分方法 9
3  结果与讨论 13
 3.1  pH对化学成盐法的影响 13
 3.2  还原反应中温度的影响 13
 3.3  检测数据 14
4  总结与展望 16
致谢 17
参考文献 18

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