选择性催化还原卤代酮的研究

选择性催化还原卤代酮的研究

文档编号:SW083 文档字数:9367,页数:28

摘要：本研究以一系列简单的芳香族化合物和酰氯为原料，经Friedel–Crafts酰基化反应合成芳香卤代酮，该酮再在乙醇溶剂中用硼氢化钠还原制备芳香卤代醇。每次实验得到的产物都先用气相色谱进行分析，通过气相图谱中产物峰和原料峰的对比来初步判定反应进行的情况。本次实习研究了不同的芳香族化合物，不同的酰氯和反应配料比等因素对产物收率的影响，在实验过程中考察了产物的分离提纯方法，并对目标产物的生成机理进行了探讨，分析了物料配比、反应温度和催化剂对反应的影响，最后用质谱和核磁共振谱对生成的芳香卤代醇进行结构表征和确证。

关键词：Friedel–Crafts酰基化；酰氯；硼氢化钠；芳香卤代酮；芳香卤代醇

Selective Catalytic Reduction of halogenated

Abstract: In this paper, a series of simple aromatic compounds and chloride were taken as raw materials, the Halogenated aromatic ketones were got by the method of Friedel-Crafts acylation reactions. And this ketones is reduced to the halogenated aromatic alcohol by sodium borohydride in the Solvent of ethanol. The product of each experiment was analysed by gas chromatography, and the degree of the reaction is determined by comparing the raw materials peaks with the product peaks. In this exercitation, the yield of reaction which affected by the different aromatic compounds, the different chloride and the Proportion of the raw materials were studied. The method of the separation and the purification of the product were inspected in the course of the experiment. And the formation mechanism of the reaction was discussed. Then the ratio of materials, the reaction temperature and the catalyst which affected the reaction were analysed. At last, the mass spectrometry and nuclear magnetic resonance were used to Authenticate and corroborate the halogenated aromatic alcohol’s frame.

Keywords：Friedel-Crafts acylation; Chloride; Sodium borohydride; Halogenated aromatic ketone; Halogenated aromatic alcohol

目录
中文摘要 I
英文摘要 II
目录 III
1. 绪论 1
1.1 引言 1
1.2 研究现状 1
2. 实验部分 3
2.1 实验原理 3
2.2 实验仪器与试剂 4
2.3 实验步骤 5
3. 结果与讨论 9
3.1 实验结果 9
3.2 实验讨论 10
3.3 核磁和质谱分析 12
4．总结与展望 22
4.1 毕业设计总结 22
4.2 毕业设计展望 22
致谢 23
参考文献 24

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